Myocardial Ischemia in Patients with Coronary Arteries without Significant Angiographic Lesions

Authors

Keywords:

myocardial ischemia, ischemic heart disease, coronary arteries.

Abstract

Introduction: Ischemia with normal coronary arteries groups a set of heterogeneous diseases, characterized by presenting signs and symptoms of myocardial ischemia in the absence of significant epicardial coronary artery obstruction.

Objective: To describe the clinical, epidemiological and angiographic characteristics of patients with myocardial ischemia and coronary arteries without significant angiographic lesions.

Methods: An observational, descriptive, cross-sectional study was performed at the Institute of Cardiology and Cardiovascular Surgery from January 2019 to December 2021. The sample was non-probabilistic and by convenience; it consisted of 155 patients who met the inclusion and exclusion criteria. Clinical variables such as age, sex, coronary risk factors, echocardiographic findings, coronary angiography and the presence of adverse cardiovascular events were evaluated.

Results: The average age was 61 years with a predominance of women. The main coronary risk factor was arterial hypertension (62.6%). The most frequent clinical manifestation was typical angina. Thirty-two-point nine percent presented T wave alterations and 34.2% had an ejection fraction of less than 50%. 17.4% of patients presented cardiovascular adverse events; hospitalizations for heart failure were the most reported.

Conclusions: The clinical, epidemiological and angiographic characteristics of patients with myocardial ischemia and coronary arteries without significant lesions showed similar behavior to that reported in the literature reviewed.

Downloads

Download data is not yet available.

Author Biographies

Yudmila Reina Borges Moreno, Instituto Cubano de Cardiología y Cirugía Cardiovascular

Especialista de segundo grado en Cardiología.

Especialista de primer grado en MGI.

Marter en urgencias médica.

Master en Investigación en Aterosclerrosis.

Profesora e Investigadora Auxiliar

Departamento de Coronario sala B.

Misión Internacionalista en Haití y Venezuela.

Ana Margarita Jerez Castro, Instituto de Cardiología y Cirugía Cardiovascular

Especialista de segundo grado en Cardiología

Profesora e Investigadora Auxiliar

Responsable del departamento docente del ICCCV

Grisel Guevara Mirabal, Instituto de Cardiología y Cirugía Cardiovascular

Especialista de primer grado en Cardiología

Profesora Auxiliar e Investigadora Agregada

Departamento de Cardiopatía Isquémica

Responsable de la sala B coronario Intermedio  del ICCCV

Anneris Martínez Carrillo, Instituto de cardiología y Cirugía Cardiovascular

Especialista de primer grado en Cardiología

Profesora asistente e Investigadora Agregada

Departamento de Cardiopatía isquémica

Alexander Valdés Martín, Instituto de cardiología y Cirugía Cardiovascular

Especialista de segundo grado en Cardiología

Profesor e Investigador Auxiliar

Responsable de la sala de Atención Médica Internacional del ICCCV

Clara Ortuño Aguilar, Instituto de Cardiología y Cirugía Cardiovascular

Especialista de primer grado en Cardiología.

Departamento docente del ICCCV.

References

Kaski JC, Crea F, Gersh BJ, Camici PG. Reappraisal of ischemic heart disease. Circulation. 2018;138:1463-80. DOI: https://doi/10.1161/CIRCULATIONAHA.118.031373.

World Health Organization. World health statistics 2019: monitoring health for the SDGs (sustainable development goals). Ginebra: World Health Organization; 2019 [acceso 17/12/2022]. Disponible en: https://www.apps.who.int/iris/handle/10665/324835.

Oficina nacional de estadísticas e información. Anuario Estadístico de Cuba 2021. La Habana: MINSAP; 2021 [acceso 10/10/2022]; 91-5 p. Disponible en: http://www.onei.gob.cu.

Dirección de registros médicos y estadísticas de salud. Anuario Estadístico de Salud 2021. La Habana: MINSAP; 2022 [acceso 20/12/2022]. Disponible en: http://www.bvscuba.sld.cu/anuario-estadistico-de-cuba/.

Arazi HC, Iglesias R, Duronto E, Lescano A, Campisi R, Deviggiano A, et al. Isquemia miocárdica sin lesiones coronarias obstructivas: MINOCA-INOCA. Revisión para la toma de decisiones GREECO (Grupo de Estudio de Enfermedades Coronarias). Medicina (B Aires). 2020 Jun [acceso 20/12/2022];80:253-70. Disponible en: http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S0025-768020000400009.

Widmer RJ, Samuels B, Samady H, Price MJ, Jeremias A, Anderson RD, et al. The functional assessment of patients with non-obstructive coronary artery disease: expert review from an international microcirculation working group. EuroIntervention. 2019;14:1694-702. DOI: https://doi.org/10.4244/EIJ-D-18-00982

Kunadian V, Chieffo A, Camici PG, Berry C, Escaned J, Maas A, et al. An EAPCI expert consensus document on ischaemia with non-obstructive coronary arteries in collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation Endorsed by Coronary Vasomotor Disorders International Study Group. Eur Heart J. 2020;41(37):3504-20. DOI: https://doi.org/10.1093/eurheartj/ehaa503

Bairey Merz CN, Pepine CJ, Shimokawa H, Berry C. Treatment of coronary microvascular dysfunction. Cardiovasc Res. 2020 Mar [acceso 20/12/2022];116(4):856-70. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061279/.

Albadri A, Bairey Merz CN, Jhonson D, Wei J, Mehta PK, Cook-Wiens G, et al. Impact of abnormal coronary rectivity on long-term clinical outcomes in women. J Am Coll Cardiol. 2019;73:684-93. DOI: https://doi.org/10.1016/j.jacc.2018.11.040.

Lee SH, Shin D, Lee JM, van de Hoef TP, Hong D, Choi KH, et al. Clinical relevance of ischemia with nonobstructive coronary arteries according to coronary microvascular dysfunction. J Am Heart Assoc. 2022;11:e025171. DOI: https://doi.org/10.1161/JAHA.121.025171

Editorial E. Declaración de Helsinki de la Asociación Médica Mundial. Arbor. 2008 Abr [acceso 20/12/2022];184(730):349-52. Disponible en https://arbor.revistas.csic.es/index.php/arbor/article/view/183

Domínguez A, González A, Avanzas P, Gómez MA, Kaski JC. Elevated circulating soluble form of CD40 ligand in patients with cardiac Syndrome X. Atherosclerosis. 2010 Dec [acceso 22/08/2022];213:637-41. Disponible en: https://pubmed.ncbu.nlm.nih.gov/209800002/.

Hanson CA, Lu E, Ghumman SS, Ouellette ML, Löffler AI, Beller GA, et al. Long-term outcomes in patients with normal coronary arteries, nonobstructive, or obstructive coronary artery disease on invasive coronary angiography. Clin Cardiol. 2021;44:1286-95. DOI: https://doi.org/10.1002/clc.23686

Bonanni A, d’Aiello A, Pedicino D, Di Sario M, Vinci R, Ponzo M, et al. Molecular hallmarks of ischemia with non-obstructive coronary arteries: The “INOCA versus obstructive CCS” Challenge J Clin Med. 2022;11:1711. DOI: https://doi.org/10.3390/jcm11061711.

Patel S, Fung M, Liang Z, Butalia S, Anderson TJ. Temporal trends of the prevalence of angina with no obstructive coronary artery disease (ANOCA). Can J Cardiol. 2023 Jan;39(1):63-70. DOI: https://doi.org/10.1016

/j.cjca.2022.10.018.

Toya T, Ahmad A, Corban MT, Ӧzcan I, Sara JD, Faten Sebaali JE, et al. Risk stratification of patients with nonobstructive coronary artery disease using resistive reserve ratio. J Am Heart Assoc. 2021;10:e020464. DOI: https://doi.org/10.1161/JAHA.120.020464

Aziz A, Steen Hansen H, Sechtem U, Prescott E, Ong P. Sex-related differences in vasomotor function in patients with angina and unobstructed coronary arteries. JACC. 2017;70(19). DOI: http://dx.doi.org/10.1016/j.jacc.2017.09.016.

Park JY, Choi SY, Rha SW, Choi BG, Noh YK, Kim YH. Sex difference in coronary artery spasm tested by intracoronary acetylcholine provocation test in patients with nonobstructive coronary artery disease. Journal of Interventional Cardiology. 2022: a5289776. DOI: https://doi.org/10.1155/2022/5289776.

Safdar B, D’Onofrio G, Dziura J, Russell RR, Johnson C, Sinusas AJ. Prevalence and characteristics of coronary microvascular dysfunction among chest pain patients in the emergency department. European Heart Journal: Acute Cardiovascular Care. 2020;9(1):5-13. DOI: https://doi.org/10.1177/20488726187644.

Cambise N, Telesca A, Tremamunno S, Felici T, De Vita A, Filice M, et al. Clinical features and outcomes of patients with stable or unstable chest pain and no-obstructive coronary artery disease. Front Cardiovasc Med. 2022;9:951183. DOI: https://doi.org/10.3389/fcvm.2022.951183

Lee BK, Lim HS, Fearon WF, Yong A, Yamada R, Tanaka S, et al. Invasive evaluation of patients with angina in the absence of obstructive coronary artery disease. Circulation. 2015;131(12):1054-60. DOI: https://doi.org/10.1161/CIRCULATIONAHA.114.012636

Wessel TR, Arant CB, McGorray SD, Sharaf BL, Reis SE, Kerensky RA, et al. Coronary microvascular reactivity is only partially predicted by atherosclerosis risk factors or coronary artery disease in women evaluated for suspected ischemia: results from the NHLBI Women’s Ischemia Syndrome Evaluation (WISE). Clin Cardiol. 2007;30:69-74. DOI: https://doi.org/10.1002/clc.19

Addison D, Singh V, Okyere-Asante K, Okafor H. Cardiovascular outcomes of a positive nuclear stress test but negative coronary angiography in a multiethnic male predominant cohort. Niger Med J. 2014 Jan.; 55(1):14-9. DOI: https://doi.org/10.4103/0300-1652.128151 PMID: PMC4071656.

Wisniewski OW, Dydowicz F, Salamaga S, Skulik P, Migaj J, Kałuzna-Oleksy M. Risk Factors Predisposing to angina in patients with non-obstructive coronary arteries: A retrospective analysis. J Pers Med. 2022;12:1049. DOI: https://doi.org/10.3390/jpm12071049.

Gimelli A, Marzullo P, L’abbate A, Rovai D. ‘False-positive’ myocardial perfusion imaging: correlation with cardiovascular risk factors and effect on event-free survival. J Cardiovasc Med (Hagerstown). 2008 Jul;9(7):707-13. DOI: https://doi.org/10.2459/JCM.0b013e3282f5ffc1 PMID:18545071.

Gu XH, He CJ, Shen L, Han B. Association between depression and outcomes in Chinese patients with myocardial infarction and non-obstructive coronary arteries. J Am Heart Assoc. 2019;8(5):e011180. DOI: https://doi.org/10.1161/JAHA.118.011180

Templin C, Ghadri JR, Diekmann J, Napp LC, Bataiosu DR, Jaguszewski MJ, et al. Clinical features and outcomes of Takotsubo (stress) cardiomyopathy. N Engl J Med. 2015;373(10):929-38. DOI: https://doi.org/10.1056/NEJMoa1406761 .

Ghadri JR, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ, et al. International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology. Eur Heart J. 2018; 39(22):2032-46. DOI: https://doi.org/10.1093/eurheartj/ehy076

Siak J, Shufelt CL, Cook-Wiens G, Samuels B, Petersen JW, Anderson D, et al. Relationship between coronary function testing and migraine: results from the Women’s Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction project. Vessel Plus. 2021; 5:45. DOI: https://doi.org/10.20517/2574-1209.2021.55

Lee TH, Song GG, Choi SJ, Seok H, Jung JH. Relationship of rheumatoid arthritis and coronary artery disease in the Korean population: a nationwide cross-sectional study. Adv Rheumatol. 2019;59(40). DOI: https://doi.org/10.1186/s42358-019-0084-6.

Manchanda AS, Kwan AC, Ishimori M, Thomson LEJ, Li D, Berman DS, et al. Coronary microvascular disfunction in patients with systemic lupus erythematosus and chest pain. Front Cardiovasc Med. 2022 Apr;9:867155. DOI: https://doi.org/10.3389/fcmv.2022.867155.

Gulati M, Shaw LJ, Bairey Merz CN. Myocardial ischemia in women: lessons from the NHLBI WISE study. Clin Cardiol. 2012 [acceso 20/12/2022] Mar;35(3):141-8. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297966/

Bouzidi N, Messaoud MB, Maatouk F, Gamra H, Ferchichi S. Relationship between high sensitivity C-reactive protein and angiographic severity of coronary artery disease. J Geriatr Cardiol 2020;17:25-663. DOI: https://doi.org/10.11909/j.issn.1671-5411.2020.05.003

Suzuki S, Kaikita·K, Yamamoto·E, Jinnouchi·H, Tsujita K. Role of acetylcholine spasm provocation test as a pathophysiological assessment in nonobstructive coronary artery disease. Cardiovasc Interv Ther. 2021 Jan;36 (1):39-51. DOI: https://doi.org/10.1007/s12928-020-00720-z.

Handberg EM, Bairey Merz CN, Cooper-Dehoff RM, Wei J, Conlon M, Lo MC, et al. Rationale and design of the Women’s Ischemia Trial to reduce events in nonobstructive CAD (WARRIOR) trial. Am Heart J. 2021; 237:90-103. DOI: https://doi.org/10.1016/j.ahj.2021.03.011.

Montone RA, Niccoli G, Russo M, Giaccari M, Del Buono MG, Meucci MC, et al. Clinical, angiographic and echocardiographic correlates of epicardial and microvascular spasm in patients with myocardial ischaemia and non-obstructive coronary arteries. Clin Res Cardiol. 2020 Apr;109:435-43. DOI: https://doi.org/10.1007/s00392-019-01523-w

Ford TJ, Berry C. How to Diagnose and manage angina without obstructive coronary artery disease: Lessons from the British Heart Foundation CorMicA Trial. Interv Cardiol Rev. 2019 [acceso 20/12/2022];14(2):76. Disponible en: https://www.icrjournal.com/articles/Angina-Without-ObstructiveCAD-BHF-CorMicA-Trial.

Ouellette ML, Löffler AI, Beller GA, Workman VA, Holland E, Bourque JM. Clinical characteristics, sex differences, and outcomes in patients with normal or near-normal coronary arteries, non-obstructive or obstructive coronary artery disease. J Am Heart Assoc. 2018;7:e007965. DOI: https://doi.org/10.1161/JAHA.117.007965

Bustamante Gómez LV, Sarria Mosquera PD. Desenlaces cardiovasculares mayores (MACE) en pacientes con estratificación miocárdica positiva para isquemia con enfermedad coronaria no obstructiva (INOCA) [Tesis de Medicina Interna, Epidemiología y Cardiología]. Universidad del Rosario. Bogotá, Colombia; 2021. [acceso 20/08/2022]. Disponible en: https://www.repository.urosario.edu.co/bitstream/handle/10336/33779/Desenlaces%202520cardiovasculare%2520mayores%2520en%2520pacientes%2520con%2520INOCA.pdf

Published

2023-12-15

How to Cite

1.
Borges Moreno YR, Jerez Castro AM, Guevara Mirabal G, Martínez Carrillo A, Valdés Martín A, Ortuño Aguilar C. Myocardial Ischemia in Patients with Coronary Arteries without Significant Angiographic Lesions. Rev. cuba. cardiol. cir. cardiovasc. [Internet]. 2023 Dec. 15 [cited 2025 Feb. 11];29(4):e2244. Available from: https://revcardiologia.sld.cu/index.php/revcardiologia/article/view/2244

Issue

Section

Original Articles

Most read articles by the same author(s)

1 2 3 4 5 > >>