Glyflozines: Antidiabetics with cardiorenal benefit

Authors

Keywords:

sodium-glucose cotransporter, diabetes, cardiovascular clinical trials, heart failure, gliflozins, inhibitors, safety profile.

Abstract

Introduction: The results of cardiovascular safety trials of sodium-glucose cotransporter type 2 inhibitors, generically called gliflozins, evaluated and used as antidiabetics, have, in turn, prompted randomized clinical trials in the therapeutics of heart failure and diabetic nephropathy.

Objective: To review the results of clinical trials performed with glyflozines; as well as their main adverse reactions, their mechanisms of action and their place in cardiovascular and renal therapeutics.

Methods: A review of the updated national and international literature was carried out. A search was made in Google Scholar and open access articles were consulted in the PubMed and SciELO databases. The following terms were used for the search: cardiovascular, diabetes, heart failure, gliflozin, sodium-glucose cotransporter type 2 inhibitors; according to the Health Sciences descriptor.

Conclusions: Some gliflozins reduce major cardiovascular events, hospitalizations due to heart failure, and impaired renal function, independent of glycemic control. The individualization of each patient and the benefit-risk of treatment with gliflozins should always be assessed.

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Author Biographies

Ana Margarita Jerez Castro, Instituto de Cardiología y Cirugía Cardiovascular

MSc, Investigadora Auxiliar

Xiomara Castelo Villalón, Instituto de Cardiología y Cirugía Cardiovascular

MSc, Investigadora Auxiliar

Flor de la Cardidad Heres Álvarez, Instituto de Cardiología y Cirugía Cardiovascular

MSc, Investigadora Auxiliar

Loipa Galán Martínez, Instituto de Cardiología y Cirugía Cardiovascular

Investigadora Titular

References

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Published

2022-11-17

How to Cite

1.
Jerez Castro AM, Castelo Villalón X, Heres Álvarez F de la C, Galán Martínez L. Glyflozines: Antidiabetics with cardiorenal benefit. Rev. cuba. cardiol. cir. cardiovasc. [Internet]. 2022 Nov. 17 [cited 2025 Mar. 11];28(4):e1380. Available from: https://revcardiologia.sld.cu/index.php/revcardiologia/article/view/1380

Issue

Vol. 28 No. 4 (2022): Octubre-Diciembre

Section

Review Article

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