Use of miseldipine in myocardial perfusion imaging with Tc99m Tetrofosmin for viability diagnosis

Authors

  • Adlin López Díaz
  • Amalia T. Peix González
  • Felizardo Ponce Vicente
  • Rodolfo Rodríguez de la Vega
  • Ana María Maltas Pineda
  • David García Barreto

Keywords:

COMPUESTOS DE ORGANOTECNECIO/ uso diagnóstico, COMPUESTOS ORGANOFOSFORADOS/ uso diagnóstico, RADIOISOTOPOS DE TALIO/ uso diagnóstico, INFARTO DEL MIOCARDIO/ cintigrafía, NILSODIPINA/ administración & dosificación.

Abstract

With the objective of finding out if viability diagnosis based on a techtenium-labelled radiopharmaceutical may be made, myocardial perfusion imaging Tc99-Tetrofosmin in work/ rest protocole was performed on 25 patients with previous myocardial infarction and also, one third of them was injected the radiopharmaceutical 55 minutes after oral administration of 5mg of nisoldipine, which is a coronary vasodilator dihydropiridine. The outcome of tetrofosmin-niseldipine analysis was compared with myocardial perfusion imaging with Thalium performed on the same patients 20-35 days after the first test. The viability diagnosis was based on the increase of radiopharmaceutical uptake within the infarction area after nisoldipine administration in the case of tetrofosmin, and after Thalium reinjection. Out of 25 patients in the study, 18 showed viability images with Thalium reinjection and 17 with tetrofosmin (after nisoldipine). The correlation between both methods was 96 % proving that nisoldipine is an alternative for determining myocardial viability.

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Author Biographies

Adlin López Díaz

Ing. Física Nuclear. Aspirante a Investigadora.

Amalia T. Peix González

Especilaista de II Grado en Cardiología. Investigadora Agregada.

Felizardo Ponce Vicente

Lic. Física Nuclear. Investigador Agregado.

Rodolfo Rodríguez de la Vega

Especialista de I Grado en Cardiología.

Ana María Maltas Pineda

Técnico en Bioquímica Clínica.

David García Barreto

Doctor en Ciencias. Especialista de II Grado en Cardiología. Investigador Titular.

Published

2014-03-17

How to Cite

1.
López Díaz A, Peix González AT, Ponce Vicente F, Rodríguez de la Vega R, Maltas Pineda AM, García Barreto D. Use of miseldipine in myocardial perfusion imaging with Tc99m Tetrofosmin for viability diagnosis. Rev. cuba. cardiol. cir. cardiovasc. [Internet]. 2014 Mar. 17 [cited 2025 Mar. 12];13(1). Available from: https://revcardiologia.sld.cu/index.php/revcardiologia/article/view/442

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Section

Original Articles