Bile acids and the heart: current evidence
Keywords:
bile acids, heart, sudden deathAbstract
Introduction: New evidence reveals the regulatory actions of bile acids as signaling molecules that benefit the balance of cardiac hemodynamics, but whose cardiotoxic effects, associated with comorbidities, cause arrhythmias, atrioventricular block, cardiac arrest and sudden death.
Objective: To present the molecular foundations that allow bile acids to be recognized as cardiotoxic agents.
Methods: A systematic review was carried out between 1939 and 2023, in PubMed, SciELO, Lilacs and Elservier of the reports about the molecular mechanisms that could constitute the theoretical foundation of the cardiotoxic effects of bile acids on myocytes. Likewise, the imbalance of the microbiota-hepatobiliary-intestinal-brain axis that leads to disorders of cardiac hemodynamics and sudden death.
Results: The molecular mechanisms that could underlie the link between the cardiotoxic effects of bile acids, dysbiosis, disorders of cardiac dynamics and sudden death are described.
Conclusion: The biomolecular foundations that recognize bile acids as cardiotoxic agents are identified and scientifically support the importance of these molecules in the diagnosis, prognosis and therapeutics of sudden death and cardiovascular diseases.
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Copyright (c) 2025 Felipe Neri Piñol Jimènez, Virginia de los Ángeles Capo de Paz, Teresita Monteros González, Hilev de las Mercedes Larrondo Muguercia, Néstor Emilio Clavería Centurión
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