Nuevos factores de riesgo asociados a enfermedades cardiovasculares

Geovanna Cedeño Pilco, Nelson Alfredo Campos Vera, Eduardo Rivas Estany

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Los factores de riesgo implicados en el desarrollo o padecimiento de las enfermedades cardiovasculares pueden ser modificables y no modificables; su reconocimiento y evaluación a menudo se considera un primer paso en el tratamiento clínico. En el caso contrario de no seguimiento terapéutico se incrementaría la carga de morbilidad y mortalidad. Existe un sinnúmero de entidades, tanto fisiológicas como patológicas, que hay que tener en cuenta como posibles asociaciones de factores de riesgo en las enfermedades cardiovasculares.

Palabras clave

enfermedades cardiovasculares; factores de riesgo cardiovasculares.


Roth GA, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, et al. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018 [acceso 21/01/2023];392(10159):1736-88. Disponible en:

Fuster V. Global burden of cardiovascular disease: time to implement feasible strategies and to monitor results. J Am Coll Cardiol. 2014[acceso 21/01/2023];64(5):520-2. Disponible en:

Mensah GA, Moran AE, Roth GA, Narula J. The global burden of cardiovascular diseases, 1990-2010. Glob Heart. 2014;9(1):183-4. DOI:

Bejarano JM, Cuixart CB. Factores de riesgo cardiovascular y atención primaria: evaluación e intervención [Cardiovascular risk factors and Primary Care: evaluation and intervention]. Aten Primaria. 2011;43(12):668-77. DOI:

Maiques A, Brotons C, Villar F, Navarro J, Lobos J, Ortega R, et al. “Recomendaciones preventivas cardiovasculares” [Preventive cardiovascular recommendations]. Aten Primaria. 2012 [acceso 24/01/2023];44(1):3-15. Disponible en:

Strelitz J, Ahern AL, Long GH, Hare MJL, Irving G, Boothby CE, et al. Moderate weight change following diabetes diagnosis and 10 years incidence of cardiovascular disease and mortality. Diabetología. 2019[acceso 24/01/2023];62(8):1391-402. Disponible en:

Webb D, Dales J, Zaccardi F, Hill S, Moore C, Farooqi A, et al. Intensive versus standard multifactorial cardiovascular risk factor control in screen-detected type 2 diabetes: 5-year and longer-term modelled outcomes of the ADDITION-Leicester study. Diabetes Metab Res Rev.;2019;35(3):e3111. DOI:

Lean ME, Leslie WS, Barnes AC, Brosnahan N, Thom G, McCombie L, et al. Primary care-led weight management for remission of type 2 diabetes (DIRECT): an open-label, cluster-randomised trial. Lancet Lond Engl. 2018;10;391(10120):541-51. DOI:

Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts). Developed with the special contribution of the European Association for Cardiovascular Prevention and Rehabilitation (EACPR). Eur Heart J. 2016;37(29):2315-81. DOI:

Sattar N, Rawshani A, Franzén S, Rawshani A, Svensson AM, Rosengren A, et al. Age at diagnosis of type 2 diabetes mellitus and associations with cardiovascular and mortality risks. Circulation. 2019;139(19):2228-37. DOI: https://doi,org/10.1161/CIRCULATIONAHA.118.037885

Rawshani A, Sattar N, Franzén S, Rawshani A, Hattersley AT, Svensson AM, et al. Excess mortality and cardiovascular disease in young adults with type 1 diabetes in relation to age at onset: a nationwide, register based cohort study. Lancet Lond Engl. 2018;392:477-86. DOI:

McAllister DA, Read SH, Kerssens J, Livingstone S, McGurnaghan S, Jhund P, et al. Incidence of hospitalization for heart failure and case-fatality among 3.25 million people with and without diabetes mellitus. Circulation. 2018;138:2774-86. DOI:

Hippisley-Cox J, Coupland C, Brindle P. Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study. BMJ. 2017;23:357. DOI:

Barnes M, Heywood AE, Mahimbo A, Rahman B, Newall AT, MaCintyre CR. Acute myocardial infarction and influenza: a meta-analysis of case–control studies. Heart Br Cardiac Soc. 2015;101:1738-47. DOI:

Nguyen JL, Yang W, Ito K, Matte TD, Shaman J, Kinney PL. Seasonal influenza infections and cardiovascular disease mortality. JAMA Cardiol 2016;1:274-81. DOI:

Kwong JC, Schwartz KL, Campitelli MA, Chung MP, Crowcroft N, Karnauchow T, et al. Acute myocardial infarction after laboratory-confirmed influenza infection. N Engl J Med. 2018 [acceso 21/10/2022];378(4):345-53. Disponible en:

Clar C, Oseni Z, Flowers N, Keshtkar J, Rees K. Influenza vaccines for preventing cardiovascular disease. Cochrane Database Syst Rev. 2015(5):CD005050. DOI:

Berlin-Broner Y, Febbraio M, Levin L. Association between apical periodontitis and cardiovascular diseases: a systematic review of the literature. Int Endod J. 2017[acceso 21/10/2022]];50:847-59. Disponible en:

Beukers NG, Heijden GJ, Wijk AJ, Loos BG. Periodontitis is an independent risk indicator for atherosclerotic cardiovascular diseases among 60 174 participants in a large dental school in the Netherlands. J Epidemiol Commun Health. 2017 [acceso 16/11/2023];71:37-42. Disponible en:

Hansen GM, Egeberg A, Holmstrup P, Hansen P. Relation of periodontitis to risk of cardiovascular and all-cause mortality (from a Danish nationwide cohort study). Am J Cardiol 2016;118:489-93. DOI:

Xu S, Song M, Xiong Y, Liu X, He Y, Qin Z. The association between periodontal disease and the risk of myocardial infarction: a pooled analysis of observational studies. BMC Cardiovasc Disord. 2017 [acceso 15/11/2023];17:50. Disponible en

Li C, Lv Z, Shi Z, Ye Z, Yafei W, Longjiang L, et al. Periodontal therapy for the management of cardiovascular disease in patients with chronic periodontitis. Cochrane Database Syst Rev. 2014;8:CD009197. DOI:

Mustian KM, Alfano CM, Heckler C, Kleckner A, Kleckner I, Leach C, et al. Comparison of pharmaceutical, psychological, and exercise treatments for cancer-related fatigue: a meta-analysis. JAMA Oncol. 2017;3(7):961-8. DOI:

Howden EJ, Bigaran A, Beaudry R, Steve F, Steve S, Antill Y, et al. Exercise as a diagnostic and therapeutic tool for the prevention of cardiovascular dysfunction in breast cancer patients. Eur J Prev Cardiol. 2019 [acceso 15/11/2023];26(3):305-15. Disponible en:

Cardinale D, Biasillo G, Salvatici M, Sandri M, Cipolla C. Using biomarkers to predict and to prevent cardiotoxicity of cancer therapy. Expert Rev Mol Diagn. 2017 [acceso 21/01/2023];17(3):245-56. Disponible en:

Baena J, García M, Comas M, Ramos R, Prieto D, Salvador B, et al. Association between chronic immune-mediated inflammatory diseases and cardiovascular risk. Heart Br Cardiac Soc. 2018 [acceso 21/01/2023];104:119-26. Disponible en:

Agca R, Heslinga SC, Rollefstad S, Heslinga M, McInnes IB, Peters MJL, et al. EULAR Recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update. Ann Rheum Dis 2017;76:17-28. DOI:

Drager LF, McEvoy RD, Barbe F, Lorenzi G, Redline S. INCOSACT Initiative (International Collaboration of Sleep Apnea Cardiovascular Trialists). Sleep Apnea and cardiovascular disease: lessons from recent trials and need for team science. Circulation. 2017 [acceso 21/11/2023];136:1840.50. Disponible en:

Kapur VK, Auckley DH, Chowdhuri S, Kuhlmann D, Mehra R, Ramar K, et al. Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med JCSM: Official Publication of the American Academy of Sleep Medicine 2017;13:479-504. DOI:

Banks E, Joshy G, Abhayaratna WP, Kritharides L, Macdonald P, Korda R, et al. Erectile dysfunction severity as a risk marker for cardiovascular disease hospitalization and all-cause mortality: a prospective cohort study. PLoS Med. 2013[acceso 21/01/2023];10(1):e1001372. Disponible en:

Adelborg K, Szepligeti SK, Holland-Bill L, Vera E, Horváth E, Henderson V, et al. Migraine and risk of cardiovascular diseases: Danish population based matched cohort study. BMJ. 2018 [acceso 21/01/2023];360:k96. Disponible en:

Mahmoud AN, Mentias A, Elgendy AY, Qazi A, Barakat A, Saad Marwan, et al. Migraine and the risk of cardiovascular and cerebrovascular events: a meta-analysis of 16 cohort studies including 1,152,407 subjects. BMJ Open. 2018;27;8(3):e020498. DOI:

Andersson C, Vasan RS. Epidemiology of cardiovascular disease in young individuals. Nat Rev Cardiol 2018;15:230-40. DOI:

De Ferranti SD, Rodday AM, Mendelson MM, Wong J, Laurel L, Sheldrick C. Prevalence of familial hypercholesterolemia in the 1999 to 2012 United States National Health and Nutrition Examination Surveys (NHANES). Circulation. 2016[acceso 21/01/2023];133:1067-72. Disponible en:

Williams B, Mancia G, Spiering W, Agabiti E, Azizi M, Burnier M, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. European Heart Journal. 2018 [acceso 21/10/2023];39:3021-104. Disponible en:

Caselli S, Vaquer A, Lemme E, Filippo M, Milan A, Flavio M, et al. Prevalence and management of systemic hypertension in athletes. Am J Cardiol. 2017;119:1616-22. DOI:

Vaes B, Depoortere D, Van Pottelbergh G, Mathet C, Neto J, Degryse J. Association between traditional cardiovascular risk factors and mortality in the oldest old: untangling the role of frailty. BMC Geriatr. 2017;17:234. DOI:

Anker D, Santos B, Santschi V, Del Giovane C, Wolfson C, Streit Sven, et al. Screening and treatment of hypertension in older adults: less is more? Public Health Rev. 2018 [acceso 21/10/2023];39:26. Disponible en:

Mortensen MB, Falk E. Primary prevention with statins in the elderly. J Am Coll Cardiol. 2018;71:85-94. DOI:

Armitage J, Baigent C, Barnes E, John Betteridge D, Blackwell L, Blazing M, et al. Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomized controlled trials. Lancet. 2019;393:407-15. DOI:

Groenhof TKJ, van Rijn BB, Franx A, Franx Arie, Roeters J, Bots M, et al. Preventing cardiovascular disease after hypertensive disorders of pregnancy: Searching for the how and when. Eur J Prev Cardiol. 2017;24: 1735–45. DOI:

Peters SA, Woodward M. Women’s reproductive factors and incident cardiovascular disease in the UK Biobank. Heart Br Cardiac Soc. 2018 [acceso 21/01/2023];104:1069-75. Disponible en:

Benjamin E, Blaha M, Chiuve S, Cushman M, Das S, Deo R, et al. Heart disease and stroke statistics–2017 update: a report from the American Heart Association. Circulation. 2017;135(10):e146-e603. DOI:

Organización Panamericana de la Salud. OPS. 2020 [acceso 21/01/2023]. La OMS declara que el nuevo brote de coronavirus es una emergencia de salud pública de importancia internacional. Disponible en:

Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020;579:270-3. DOI:

Zheng YY, Ma YT, Zhang JY, Xie X. COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020;17:259-60. DOI:

Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q, et al. Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Infect Dis. 2020;94:91-5. DOI:

De Rosa S, Spaccarotella C, Basso C, Calabro MP, Curcio A, Filardi PP, et al. Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era. Eur Heart J. 2020;41:2083-8. DOI:

Driggin E, Madhavan MV, Bikdeli B, Chuich T, Laracy J, Biondi-Zoccai G, et al. Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic. J Am Coll Cardiol. 2020;75:2352-71. DOI:

Pappa S, Ntella V, Giannakas T, Giannakoulis VG, Papoutsi E, Katsaounou P. Prevalence of depression, anxiety, and insomnia among healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis. Brain Behav Immun 2020;S0889-1591(20)30845-X. Online ahead of print. DOI:

Fuster V, Varieur Turco J. COVID-19: A Lesson in Humility and an Opportunity for Sagacity and Hope. J Am Coll Cardiol 2020;75:2625-6. DOI:

Chan JW, Ng CK, Chan YH, Mok TY, Lee S, Chu SY, et al. Short-term outcome and risk factors for adverse clinical outcomes in adults with severe acute respiratory syndrome (SARS). Thorax. 2003 [acceso 21/01/2023];58(8):686-9. Disponible en:

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